Inputs and outputs of poly(ADP-ribosyl)ation

Relevance to oxidative stress

Csaba Hegedus, L. Virag

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Oxidative stress can cause DNA breaks which induce activation of the DNA nick sensor enzyme poly(ADP-ribose) polymerase-1 (PARP-1), part of the 17 member PARP enzyme family. PARP-1 modifies target proteins by attaching to them several NAD-derived ADP-ribose units forming poly(ADP-ribose) (PAR) polymers. PARylation controls many cellular processes while intense PARylation may also lead to cell death by various mechanisms. Here we summarize the modes of activation, inhibitors and modulators of PARP-1 and review the cellular functions regulated by the enzyme.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalRedox Biology
Volume2
Issue number1
DOIs
Publication statusPublished - Aug 21 2014

Fingerprint

Oxidative stress
Poly(ADP-ribose) Polymerases
Adenosine Diphosphate
Oxidative Stress
Enzyme sensors
Enzymes
Chemical activation
Adenosine Diphosphate Ribose
Poly Adenosine Diphosphate Ribose
Single-Stranded DNA Breaks
DNA Breaks
DNA
Cell death
NAD
Modulators
Polymers
Cell Death
Poly (ADP-Ribose) Polymerase-1
Proteins

Keywords

  • Apoptosis
  • Cell death
  • Necroptosis
  • Oxidative stress
  • PARP1
  • Poly(ADP-ribosyl)ation

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

Cite this

Inputs and outputs of poly(ADP-ribosyl)ation : Relevance to oxidative stress. / Hegedus, Csaba; Virag, L.

In: Redox Biology, Vol. 2, No. 1, 21.08.2014, p. 1-5.

Research output: Contribution to journalArticle

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