Input impedance and peripheral inhomogeneity of dog lungs

Z. Hantos, B. Daroczy, B. Suki, S. Nagy, J. J. Fredberg

Research output: Contribution to journalArticle

582 Citations (Scopus)

Abstract

Tracheal pressure, central airflow, and alveolar capsule pressures in cardiac lobes were measured in open-chest dogs during 0.1- to 20-Hz pseudorandom forced oscillations applied at the airway opening. In the interval 0.1-4.15 Hz, the input impedance data were fitted by four-parameter models including frequency-independent airway resistance and inertance and tissue parts featuring a marked negative frequency dependence of resistance and a slight elevation of elastance with frequency. The models gave good fits both in the control state and during histamine infusion. At the same time, the regional transfer impedances (alveolar pressure-to-central airflow ratios) showed intralobar and interlobar variabilities of similar degrees, which increased with frequency and were exaggerated during histamine infusion. Results of simulation studies based on a lung model consisting of a central airway and a number of peripheral units with airway and tissue parameters that were given independent wide distributions were in agreement with the experimental findings and showed that even an extremely inhomogeneous lung structure can produce virtually homogeneous mechanical behavior at the input.

Original languageEnglish
Pages (from-to)168-178
Number of pages11
JournalJournal of Applied Physiology
Volume72
Issue number1
Publication statusPublished - 1992

Fingerprint

Electric Impedance
Dogs
Pressure
Lung
Histamine
Airway Resistance
Capsules
Thorax

Keywords

  • alveolar pressures
  • forced oscillations
  • histamine infusion
  • pulmonary impedance
  • tissue impedance

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Hantos, Z., Daroczy, B., Suki, B., Nagy, S., & Fredberg, J. J. (1992). Input impedance and peripheral inhomogeneity of dog lungs. Journal of Applied Physiology, 72(1), 168-178.

Input impedance and peripheral inhomogeneity of dog lungs. / Hantos, Z.; Daroczy, B.; Suki, B.; Nagy, S.; Fredberg, J. J.

In: Journal of Applied Physiology, Vol. 72, No. 1, 1992, p. 168-178.

Research output: Contribution to journalArticle

Hantos, Z, Daroczy, B, Suki, B, Nagy, S & Fredberg, JJ 1992, 'Input impedance and peripheral inhomogeneity of dog lungs', Journal of Applied Physiology, vol. 72, no. 1, pp. 168-178.
Hantos, Z. ; Daroczy, B. ; Suki, B. ; Nagy, S. ; Fredberg, J. J. / Input impedance and peripheral inhomogeneity of dog lungs. In: Journal of Applied Physiology. 1992 ; Vol. 72, No. 1. pp. 168-178.
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