Inositol phospholipid turnover and protein kinase C translocation are stimulated by poly(I) · poly(C) in human amnion cells (UAC)

György Premecz, Andrea Markovits, György Bagi, T. Farkas, István Földes

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Polyinosinic-polycytidylic acid, a potent inducer of interferon (IFN) production and activator of some IFN-induced enzymes, inhibits [3H]uridine incorporation into the RNA of vesicular stomatitis virus even in the absence of IFN synthesis, transiently triggers the breakdown of inositol phospholipids and activates the translocation of protein kinase C. Since IFNs also have similar activities these results suggest that IFN induction and IFN function are realised through common biochemical pathways.

Original languageEnglish
Pages (from-to)13-16
Number of pages4
JournalFEBS Letters
Volume226
Issue number1
DOIs
Publication statusPublished - Dec 21 1987

Fingerprint

Poly I
Poly C
Poly I-C
Amnion
Phosphatidylinositols
Protein Kinase C
Interferons
Interferon Inducers
Vesicular Stomatitis
Uridine
Viruses
RNA
Enzymes

Keywords

  • Antiviral activity
  • Interferon function
  • Interferon induction
  • Phosphatidylinositol turnover
  • Poly (I) · poly(C)
  • Protein kinase C

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Inositol phospholipid turnover and protein kinase C translocation are stimulated by poly(I) · poly(C) in human amnion cells (UAC). / Premecz, György; Markovits, Andrea; Bagi, György; Farkas, T.; Földes, István.

In: FEBS Letters, Vol. 226, No. 1, 21.12.1987, p. 13-16.

Research output: Contribution to journalArticle

Premecz, György ; Markovits, Andrea ; Bagi, György ; Farkas, T. ; Földes, István. / Inositol phospholipid turnover and protein kinase C translocation are stimulated by poly(I) · poly(C) in human amnion cells (UAC). In: FEBS Letters. 1987 ; Vol. 226, No. 1. pp. 13-16.
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