Innervation of the adrenal cortex, its physiological relevance, with primary focus on the noradrenergic transmission

Ida E. Tóth, E. Sylvester Vizi, Joy P. Hinson, Gavin P. Vinson

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19 Citations (Scopus)


The current knowledge of the catecholaminergic innervation of the mammalian adrenal cortex is summarized, and macro- and microscopic neuromorphology, including the central nervous system connections of the adrenal cortex, is briefly discussed. Morphological and functional data on the catecholaminergic (i.e., noradrenergic) innervation of the adrenal cortex are reviewed. Experimental data suggest that in addition to the regulation of adrenal blood flow, the noradrenergic innervation has a primary influence on zona glomerulosa cells possibly via β1 adrenergic and depaminergic receptors (DA2 subtype via inhibiting T-type Ca2+ channels). It is concluded that the local, modulatory effect of noradrenergic nerve fibres, terminating in the close vicinity of the zona glomerulosa cells, on the systemic renin-angiotensin-aldosterone and other peptide cascade may be influenced by neuropeptides, particularly neuropeptide Y and vasoactive intestinal peptide.

Original languageEnglish
Pages (from-to)534-545
Number of pages12
JournalMicroscopy Research and Technique
Issue number6
Publication statusPublished - May 24 1997



  • catecholamine immunohistochemistry
  • neuron-endocrine cell cross talk
  • paracrine regulation
  • patch clamp

ASJC Scopus subject areas

  • Anatomy
  • Histology
  • Instrumentation
  • Medical Laboratory Technology

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