Innervation and serotoninergic receptors of the testis interact with local action of interleukin-1beta on steroidogenesis

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Abstract

Testosterone secretion by Leydig cells is affected by interleukin-1β (IL-1β). The aim of the present study was to investigate whether partial denervation of the testis or local administration of a serotonin (5-HT) receptor antagonist could alter the changes in testicular steoidogenesis induced by IL-1β. Intratesticular administration of IL-1β was combined with vasectomy or local injection of ketanserin (5-HT type 2 receptor antagonist) in immature hemicastrated rats and the effect of the interventions on testicular steroidogenesis was studied. One day after treatment with local injection of IL-1β induced a significant rise in testosterone secretion that could be prevented by vasectomy (that also means transection of the inferior spermatic nerve). In a model in which neither IL-1β nor ketanserin interfered with steroidogenesis, administration of the receptor antagonist just prior to IL-1β treatment significantly reduced testosterone secretion. Data indicate interaction between testicular nerves and IL-1β action and interaction between testicular 5-HT2 receptors and local effect of IL-1β on testosterone secretion.

Original languageEnglish
Pages (from-to)21-27
Number of pages7
JournalAutonomic Neuroscience: Basic and Clinical
Volume131
Issue number1-2
DOIs
Publication statusPublished - Jan 30 2007

Keywords

  • IL-1β
  • Ketanserin
  • Testicular steroidogenesis
  • Vasectomy

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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