Innate immune response and hepatic inflammation

G. Szabó, Pranoti Mandrekar, Angela Dolganiuc

Research output: Contribution to journalArticle

126 Citations (Scopus)

Abstract

Inflammation is a pathogenic component of various types of acute and chronic liver diseases, and it contributes to progressive liver damage and fibrosis. Cells of the innate immune system initiate and maintain hepatic inflammation though mediator production as a result of their activation by pathogen-derived products recognized by pattern recognition receptors. Innate immune cells, particularly dendritic cells, have a pivotal role in sensing pathogens and initiating adaptive immune responses by activation and regulation of T-lymphocyte responses. Although the liver provides a "tolerogenic" immune environment for antigen-specific T-cells, activation of Kupffer cells, recruited macrophages, and inflammatory cells results in production of cytokines and chemokines that can lead to prolonged inflammation, hepatocyte damage, and/or cholestasis. The specificity of Toll-like receptors and the mechanisms of innate immune cell activation are discussed in relation to acute and chronic liver injury including viral, alcoholic, nonalcoholic, and drug-induced hepatitis.

Original languageEnglish
Pages (from-to)339-350
Number of pages12
JournalSeminars in Liver Disease
Volume27
Issue number4
DOIs
Publication statusPublished - Nov 2007

Fingerprint

Innate Immunity
Inflammation
Liver
CD27 Antigens
Chemical and Drug Induced Liver Injury
Pattern Recognition Receptors
Inflammation Mediators
Kupffer Cells
Toll-Like Receptors
Cholestasis
Adaptive Immunity
Chemokines
Liver Cirrhosis
Dendritic Cells
Liver Diseases
Hepatocytes
Immune System
Chronic Disease
Macrophages
Cytokines

Keywords

  • Alcohol
  • Biliary
  • Chemokines
  • Fibrosis
  • Hepatitis
  • Ischemia
  • Nuclear factor kappa B
  • Virus

ASJC Scopus subject areas

  • Hepatology

Cite this

Innate immune response and hepatic inflammation. / Szabó, G.; Mandrekar, Pranoti; Dolganiuc, Angela.

In: Seminars in Liver Disease, Vol. 27, No. 4, 11.2007, p. 339-350.

Research output: Contribution to journalArticle

Szabó, G. ; Mandrekar, Pranoti ; Dolganiuc, Angela. / Innate immune response and hepatic inflammation. In: Seminars in Liver Disease. 2007 ; Vol. 27, No. 4. pp. 339-350.
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