Innate cellular immune responses in newborns

Research output: Contribution to journalArticle

155 Citations (Scopus)

Abstract

Innate immunity assures the first line of defense against pathogenic microorganisms. Innate immune responses induced by bacteria, fungi, or viral replication are triggered by granulocytes, monocytes, macrophages, dentritic cells, and natural killer cells. Neonatal deficiency of innate cellular immunity includes a decreased production of interferons, IL-12/IL-23, and IL-18, and other proinflammatory cytokines, an impaired type-1 response of macrophages to IFN-γ, the most potent macrophage-activating agent in vivo, and to lipopolysaccharide, the primary constituent of the outer membrane of Gram-negative bacteria. An increasing body of evidence suggests impaired responses of neonatal monocytes and macrophages to multiple TLR ligands. This review will discuss recent advances in understanding innate cellular immunity in human neonates, with respect to selected aspects of immune functions that may be related to increased susceptibility to infections. Components of TLR signaling and the immune consequence that may result from neonatal deficiencies will be highlighted. A better understanding of innate immunity can make the development of techniques possible by which physicians more accurately tailor prevention and treatment of neonatal infections.

Original languageEnglish
Pages (from-to)137-144
Number of pages8
JournalClinical Immunology
Volume118
Issue number2-3
DOIs
Publication statusPublished - Feb 2006

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Innate Immunity
Cellular Immunity
Newborn Infant
Macrophages
Monocytes
Interleukin-23
Interleukin-18
Interleukin-12
Infection
Gram-Negative Bacteria
Granulocytes
Natural Killer Cells
Interferons
Lipopolysaccharides
Fungi
Cytokines
Ligands
Bacteria
Physicians
Membranes

Keywords

  • Cytokines
  • Monocytes/Macrophages
  • Newborns
  • Toll-like receptors

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Innate cellular immune responses in newborns. / Maródi, László.

In: Clinical Immunology, Vol. 118, No. 2-3, 02.2006, p. 137-144.

Research output: Contribution to journalArticle

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