Initial experience with collagen-filled guglielmi detachable coils for endovascular treatment of experimental aneurysms

Istvan Szikora, Ajay K. Wakhloo, Lee R. Guterman, Tamerla D. Chavis, Robert C. Dawson, Robert W. Hergenrother, Robert H. Twyford, L. Nelson Hopkins

Research output: Contribution to journalArticle

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Abstract

PURPOSE: To evaluate the effectiveness of Guglielmi detachable coils (GDCs) filled with collagen threads in the permanent treatment of experimental aneurysms. METHODS: Seventeen side-wall aneurysms were surgically constructed in the canine common carotid artery; six were treated with conventional GDCs and 11 with collagen-filled GDCs. One aneurysm was removed at 1 week, the others were studied by digital subtraction angiography for a period of 3 to 12 weeks. Longitudinal sections of all aneurysms were examined by light microscopy. RESULTS: Angiograms obtained throughout the follow-up period showed no significant difference between aneurysms treated with conventional GDCs and those treated with collagen-filled GDCs. Light microscopy revealed a dense meshwork of newly formed collagen and fibroblasts near the collagen-filled GDCs, whereas a loose cellular meshwork surrounded the conventional GDCs at 8 and 12 weeks after treatment. CONCLUSION: Collagen threads within GDCs do not noticeably improve angiographic treatment of experimental aneurysms; however, these threads did induce local proliferation of fibroblasts and production of collagen within the aneurysmal cavities.

Original languageEnglish
Pages (from-to)667-672
Number of pages6
JournalAmerican Journal of Neuroradiology
Volume18
Issue number4
Publication statusPublished - Apr 1997

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Aneurysm
Collagen
Microscopy
Fibroblasts
Light
Digital Subtraction Angiography
Common Carotid Artery
Canidae
Angiography

Keywords

  • Aneurysm, embolization
  • Animal studies
  • Interventional instruments, coils

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Szikora, I., Wakhloo, A. K., Guterman, L. R., Chavis, T. D., Dawson, R. C., Hergenrother, R. W., ... Hopkins, L. N. (1997). Initial experience with collagen-filled guglielmi detachable coils for endovascular treatment of experimental aneurysms. American Journal of Neuroradiology, 18(4), 667-672.

Initial experience with collagen-filled guglielmi detachable coils for endovascular treatment of experimental aneurysms. / Szikora, Istvan; Wakhloo, Ajay K.; Guterman, Lee R.; Chavis, Tamerla D.; Dawson, Robert C.; Hergenrother, Robert W.; Twyford, Robert H.; Hopkins, L. Nelson.

In: American Journal of Neuroradiology, Vol. 18, No. 4, 04.1997, p. 667-672.

Research output: Contribution to journalArticle

Szikora, I, Wakhloo, AK, Guterman, LR, Chavis, TD, Dawson, RC, Hergenrother, RW, Twyford, RH & Hopkins, LN 1997, 'Initial experience with collagen-filled guglielmi detachable coils for endovascular treatment of experimental aneurysms', American Journal of Neuroradiology, vol. 18, no. 4, pp. 667-672.
Szikora, Istvan ; Wakhloo, Ajay K. ; Guterman, Lee R. ; Chavis, Tamerla D. ; Dawson, Robert C. ; Hergenrother, Robert W. ; Twyford, Robert H. ; Hopkins, L. Nelson. / Initial experience with collagen-filled guglielmi detachable coils for endovascular treatment of experimental aneurysms. In: American Journal of Neuroradiology. 1997 ; Vol. 18, No. 4. pp. 667-672.
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