Clinical experience supports, that Strogen Forte (standardized extract of plant Sabalis Serrulatae) can be applied successfully in the medical treatment of benign prostatic hyperplasia (BPH). Mechanism of action of this phytopharmacon has not yet been clarified however, some reported data suggest that this drug is able to inhibit the action of 5α-reductase. This enzyme catalyzed the transformation of testosterone into 5α-dihydrotestosterone, thus influencing he growth and function of the prostatic gland. The aim of the present study was to investigate a possible inhibitory effect on rat and human prostatic 5α-reductase. The experimental results clearly demonstrate that Strogen Forte is a potent and direct inhibitor, 385 ± 6 μg/ml for that and 245 ± 65 μg/ml human prostatic 5α-reductase, were exhibited. These in vitro results suggest that Strogen Forte may act as an in vivo 5α-reductase inhibitor, too and this mechanism may participate in its BPH-reducing therapeutic effectivity.
|Translated title of the contribution||Inhibitory effects of Strogen Forte extract on the activities of rat and human prostatic 5α-reductase in vitro|
|Number of pages||7|
|Publication status||Published - Dec 5 1996|
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