Inhibitory effects of hypertonic saline on P. aeruginosa motility

Viktória Havasi, Casey O. Hurst, Travis C. Briles, Fan Yang, David G. Bains, Daniel J. Hassett, Eric Sorscher

Research output: Contribution to journalEditorial

22 Citations (Scopus)

Abstract

Salt transport defects in CF lungs predispose to overwhelming and fatal respiratory infection caused by Pseudomonas aeruginosa. Motility of this organism is central to pathogenesis in a number of settings. Incubation of numerous strains of P. aeruginosa with hypertonic saline caused a concentration-dependent decrease in bacterial motility. Reduction of P. aeruginosa virulence through this effect may contribute to clinical efficacy of hypertonic saline aerosols in CF patients.

Original languageEnglish
Pages (from-to)267-269
Number of pages3
JournalJournal of Cystic Fibrosis
Volume7
Issue number4
DOIs
Publication statusPublished - Jul 1 2008

Keywords

  • Cystic fibrosis
  • High salt
  • Mucociliary clearance

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

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    Havasi, V., Hurst, C. O., Briles, T. C., Yang, F., Bains, D. G., Hassett, D. J., & Sorscher, E. (2008). Inhibitory effects of hypertonic saline on P. aeruginosa motility. Journal of Cystic Fibrosis, 7(4), 267-269. https://doi.org/10.1016/j.jcf.2007.11.009