Inhibitory effects of cysteine and cysteine derivatives on germination of sporangiospores and hyphal growth of different Zygomycetes

László Galgóczy, Laura Kovács, Krisztina Krizsán, T. Papp, C. Vágvölgyi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The in vitro antifungal activity of cysteine (D- and L-cysteine) and its four derivatives (L-cysteine-methyl-ester, N-acetyl-cysteine, N-isobutyryl-D-cysteine, and N-isobutyryl-L-cysteine) were investigated on 20 fungal isolates representing 16 genera (Absidia, Actinomucor, Backusella, Gilbertella, Micromucor, Mortierella, Mucor, Mycotypha, Phycomyces, Rhizomucor, Rhizopus, Saksenaea, Syncephalastrum, Thamnostylum, Umbellopsis, and Zygorynchus). The inhibitory potential of different concentrations of these compounds, ranging from 0.625 to 10 mM, were investigated on the germination of sporangiospores as well as on hyphal extension, using broth microdilution method and agar plate test. Treatment with cysteine and its derivatives resulted in a strong inhibition in most studied strains. At 10 mM of compounds, complete blockage of growth was observed for some isolates. Sensitive species exhibited severe changes in colony morphology in the presence of 10 mM L-cysteine, N-acetyl-cysteine, and N-isobutyryl-L-cysteine. Microscopic observations revealed that 10 mM N-acetyl-cysteine induced dramatic modifications in the structural organization of the hyphae. Results suggest that cysteine and its derivatives have a therapeutic potential against fungal infections caused by Zygomycetes species.

Original languageEnglish
Pages (from-to)125-134
Number of pages10
JournalMycopathologia
Volume168
Issue number3
DOIs
Publication statusPublished - 2009

Fingerprint

Germination
Cysteine
cysteine
chemical derivatives
germination
Growth
acetylcysteine
Saksenaea
Mycotypha
Gilbertella
Syncephalastrum
Rhizomucor
Absidia
Mortierella
Phycomyces
Mucor
Rhizopus
Hyphae
Mycoses
Acetylcysteine

Keywords

  • Antifungal activity
  • Cysteine
  • Cysteine derivatives
  • Zygomycetes

ASJC Scopus subject areas

  • Plant Science
  • Agronomy and Crop Science
  • Applied Microbiology and Biotechnology
  • Microbiology
  • veterinary (miscalleneous)

Cite this

Inhibitory effects of cysteine and cysteine derivatives on germination of sporangiospores and hyphal growth of different Zygomycetes. / Galgóczy, László; Kovács, Laura; Krizsán, Krisztina; Papp, T.; Vágvölgyi, C.

In: Mycopathologia, Vol. 168, No. 3, 2009, p. 125-134.

Research output: Contribution to journalArticle

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