A metil-xantinok gátló hatása a juhok praeeclampsia betegségének kialakulására

Translated title of the contribution: Inhibitory effects methilxanthines on preeclamsia of ewes

Tálosi Gyula, I. Németh, S. Pintér

Research output: Contribution to journalArticle

Abstract

We hypothesized that two methylxanthines, pentoxifylline and allopurinol, would have beneficial effects on experimental pregnancy-induced pre-eclampsia in ewes. 20 animals at the gestational age of 130-135 days were divided into 4 groups (control; fasting; fasting, pentoxifylline-treated; and fasting, allopurinoltreated). The illness was provoked with a 4-day fasting period. Electrolytes, glucose, conventional parameters, plasma haem content, indirect bilirubin concentration and free thiol levels were measured. Unlike in the fasting group, conventional signs of the disease, such as hypertension, kidney and liver injury and platelet count decrease, were all mitigated in the fasting, drug-treated animals. In the treated animals plasma haemoglobin/haem content increased by a less significant level, while indirect bilirubin concentration showed a more rapid rise. Both methylxanthines had inhibitory effects on the development of the symptoms of the illness. We speculate that besides the well-known effects of the two drugs the better induction of haem oxygenase might be also important in the inhibition of the development of the pre-eclamptic disease in ewes.

Original languageHungarian
Pages (from-to)411-417
Number of pages7
JournalMagyar Noorvosok Lapja
Volume65
Issue number6
Publication statusPublished - 2002

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Fasting
Pentoxifylline
Heme
Bilirubin
Heme Oxygenase (Decyclizing)
Allopurinol
Pre-Eclampsia
Platelet Count
Sulfhydryl Compounds
Pharmaceutical Preparations
Electrolytes
Gestational Age
Hemoglobins
Hypertension
Kidney
Glucose
Pregnancy
Control Groups
Liver
Wounds and Injuries

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

A metil-xantinok gátló hatása a juhok praeeclampsia betegségének kialakulására. / Gyula, Tálosi; Németh, I.; Pintér, S.

In: Magyar Noorvosok Lapja, Vol. 65, No. 6, 2002, p. 411-417.

Research output: Contribution to journalArticle

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