Inhibitory effect of tumour cells on leukocyte motility

L. Kalmar, K. Gyires, P. Gergely

Research output: Contribution to journalArticle

3 Citations (Scopus)


Hep-2 cells inhibit the random migration of human polymorphonuclear leukocytes in a tumour cell-leukocyte microenvironmental model, which is a special form of co-migration. The inhibition is indomethacin-sensitive. It is very likely that prostaglandins, produced as a consequence of interaction between tumour cells and leukocytes, are the mediators of this phenomenon. The tumour-induced inhibition of leukocyte motility may represent a tumour-protective mechanism.

Original languageEnglish
Pages (from-to)175-177
Number of pages3
JournalImmunology letters
Issue number4
Publication statusPublished - 1984


  • Hep-2 tumour cells
  • granulocyte motility
  • prostaglandins

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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