Inhibitory effect of tumour cells on leukocyte motility

L. Kalmar, K. Gyires, P. Gergely

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Hep-2 cells inhibit the random migration of human polymorphonuclear leukocytes in a tumour cell-leukocyte microenvironmental model, which is a special form of co-migration. The inhibition is indomethacin-sensitive. It is very likely that prostaglandins, produced as a consequence of interaction between tumour cells and leukocytes, are the mediators of this phenomenon. The tumour-induced inhibition of leukocyte motility may represent a tumour-protective mechanism.

Original languageEnglish
Pages (from-to)175-177
Number of pages3
JournalImmunology Letters
Volume8
Issue number4
DOIs
Publication statusPublished - 1984

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Leukocytes
Neoplasms
Indomethacin
Prostaglandins
Neutrophils

Keywords

  • granulocyte motility
  • Hep-2 tumour cells
  • prostaglandins

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Inhibitory effect of tumour cells on leukocyte motility. / Kalmar, L.; Gyires, K.; Gergely, P.

In: Immunology Letters, Vol. 8, No. 4, 1984, p. 175-177.

Research output: Contribution to journalArticle

Kalmar, L. ; Gyires, K. ; Gergely, P. / Inhibitory effect of tumour cells on leukocyte motility. In: Immunology Letters. 1984 ; Vol. 8, No. 4. pp. 175-177.
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