Δ5-3β-hydroxysteroid dehydrogenase (Δ5-3β-HSD) is a key enzyme in the biosynthesis of biologically active steroid hormones and a major determinant of androgens (especially of testosterone) produced mainly by the testicles. Strogen Forte (standardized extract of plant Sabalis Serrulata) were examined on in vitro activities of rat and human testicular Δ5-3β-HSD. In the present experiments, Strogen Forte proved to be a direct inhibitor with medium effectivity and it exerted similar IC50 parameters of inhibition for both rat testicular Δ5-3β-HSD (400 ± 23 μ/ml) and human testicular Δ5-3β-HSD (212 ± 8.6 μ/ml), This study indicates a novel mechanism of antiandrogenic effect of Strogen Forte.
|Translated title of the contribution||Inhibitory effect of Strogen Forte on the activities of rat and human testicular Δ5-3β-hydroxysteroid dehydrogenase in vitro|
|Number of pages||7|
|Publication status||Published - Dec 5 1996|
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