A STROGEN FORTE EXTRACTUM IN VITRO GATLO HATASA A PATKANY- ES EMBERI HERE Δ5-3β-HIDROXISZTEROID DEHIDROGENAZ ENZIM AKTIVITASARA

Translated title of the contribution: Inhibitory effect of Strogen Forte on the activities of rat and human testicular Δ5-3β-hydroxysteroid dehydrogenase in vitro

I. Toth, M. Szecsi, J. Julesz, I. Faredin, B. Behnke

Research output: Contribution to journalArticle

Abstract

Δ5-3β-hydroxysteroid dehydrogenase (Δ5-3β-HSD) is a key enzyme in the biosynthesis of biologically active steroid hormones and a major determinant of androgens (especially of testosterone) produced mainly by the testicles. Strogen Forte (standardized extract of plant Sabalis Serrulata) were examined on in vitro activities of rat and human testicular Δ5-3β-HSD. In the present experiments, Strogen Forte proved to be a direct inhibitor with medium effectivity and it exerted similar IC50 parameters of inhibition for both rat testicular Δ5-3β-HSD (400 ± 23 μ/ml) and human testicular Δ5-3β-HSD (212 ± 8.6 μ/ml), This study indicates a novel mechanism of antiandrogenic effect of Strogen Forte.

Translated title of the contributionInhibitory effect of Strogen Forte on the activities of rat and human testicular Δ5-3β-hydroxysteroid dehydrogenase in vitro
Original languageHungarian
Pages (from-to)235-241
Number of pages7
JournalMagyar Urologia
Volume8
Issue number3
Publication statusPublished - Dec 5 1996

ASJC Scopus subject areas

  • Urology

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