Inhibitory effect of PACAP-38 on acute neurogenic and non-neurogenic inflammatory processes in the rat

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Abstract

Inhibitory actions of pituitary adenylate cyclase activating polypeptide (PACAP) have been described on cellular/vascular inflammatory components, but there are few data concerning its role in neurogenic inflammation. In this study we measured PACAP-like immunoreactivity with radioimmunoassay in the rat plasma and showed a two-fold elevation in response to systemic stimulation of capsaicin-sensitive sensory nerves by resiniferatoxin, but not after local excitation of cutaneous afferents. Neurogenic plasma extravasation in the plantar skin induced by intraplantar capsaicin or resiniferatoxin, as well as carrageenan-induced paw edema were significantly diminished by intraperitoneal PACAP-38. In summary, these results demonstrate that PACAP is released from activated capsaicin-sensitive afferents into the systemic circulation. It diminishes acute pure neurogenic and mixed-type inflammatory reactions via inhibiting pro-inflammatory mediator release and/or by acting at post-junctional targets on the vascular endothelium.

Original languageEnglish
Pages (from-to)1847-1855
Number of pages9
JournalPeptides
Volume28
Issue number9
DOIs
Publication statusPublished - Sep 1 2007

Keywords

  • Capsaicin-sensitive sensory nerves
  • Carrageenan-induced edema
  • MALDI TOF
  • Plasma PACAP-like immunoreactivity
  • Resiniferatoxin
  • Sciatic nerve stimulation

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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