Inhibitory effect of monocyte reactive antibodies on monocyte chemotaxis in systemic lupus erythematosus.

G. Szegedi, K. Lukács, E. Bodolay, L. Gulácsi, I. Sonkoly, G. Szabó, J. Szöllősi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Presence of different types of autoantibodies is a basic feature of systemic lupus erythematosus (SLE). Though monocytes, macrophages play an important role in cellular immunity, autoantibodies against monocytes have not been sufficiently studied. The authors used automatic fluorochromatic assay to detect monocyte reactive autoantibodies in the sera of SLE patients. Of SLE 35.5% sera showed complement-mediated monocytotoxic activity against healthy monocytes. Monocyte reactive SLE sera as well as monoclonal antibodies against human monocytes inhibited chemotaxis of control monocytes. The results suggest that monocyte reactive autoantibodies may play a role in the decreased monocyte number and defective monocyte functions observed in SLE.

Original languageEnglish
Pages (from-to)175-183
Number of pages9
JournalHaematologia
Volume18
Issue number3
Publication statusPublished - 1985

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Chemotaxis
Systemic Lupus Erythematosus
Monocytes
Antibodies
Autoantibodies
Serum
Cellular Immunity
Macrophages
Monoclonal Antibodies

ASJC Scopus subject areas

  • Hematology

Cite this

Inhibitory effect of monocyte reactive antibodies on monocyte chemotaxis in systemic lupus erythematosus. / Szegedi, G.; Lukács, K.; Bodolay, E.; Gulácsi, L.; Sonkoly, I.; Szabó, G.; Szöllősi, J.

In: Haematologia, Vol. 18, No. 3, 1985, p. 175-183.

Research output: Contribution to journalArticle

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AU - Szegedi, G.

AU - Lukács, K.

AU - Bodolay, E.

AU - Gulácsi, L.

AU - Sonkoly, I.

AU - Szabó, G.

AU - Szöllősi, J.

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AB - Presence of different types of autoantibodies is a basic feature of systemic lupus erythematosus (SLE). Though monocytes, macrophages play an important role in cellular immunity, autoantibodies against monocytes have not been sufficiently studied. The authors used automatic fluorochromatic assay to detect monocyte reactive autoantibodies in the sera of SLE patients. Of SLE 35.5% sera showed complement-mediated monocytotoxic activity against healthy monocytes. Monocyte reactive SLE sera as well as monoclonal antibodies against human monocytes inhibited chemotaxis of control monocytes. The results suggest that monocyte reactive autoantibodies may play a role in the decreased monocyte number and defective monocyte functions observed in SLE.

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