Inhibitory effect of midbrain raphe stimulation on the maintenance of an active avoidance reflex

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5 Citations (Scopus)

Abstract

Performance of an active avoidance (bench-jumping) reflex has been studied in rats during stimulation of the midbrain raphe nuclei. Raphe stimulation (10 cps, 0.2 msec, 2.5-5.0 V) inhibited the performance of the reflex. A serotonin receptor blocker (methysergide, 2.0 mg/kg IP) increased the reflex performance in non-stimulated animals and prevented the action of raphe stimulation. The data indicate that the cerebral serotoninergic system might have an inhibitory control over the performance of conditioned avoidance reflex.

Original languageEnglish
Pages (from-to)709-711
Number of pages3
JournalPharmacology, Biochemistry and Behavior
Volume5
Issue number6
DOIs
Publication statusPublished - 1976

Fingerprint

Methysergide
Serotonin Antagonists
Reflex
Rats
Animals
Maintenance
Classical Conditioning
Midbrain Raphe Nuclei

Keywords

  • Conditioned avoidance reflex
  • Methysergide
  • Midbrain raphe stimulation

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

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abstract = "Performance of an active avoidance (bench-jumping) reflex has been studied in rats during stimulation of the midbrain raphe nuclei. Raphe stimulation (10 cps, 0.2 msec, 2.5-5.0 V) inhibited the performance of the reflex. A serotonin receptor blocker (methysergide, 2.0 mg/kg IP) increased the reflex performance in non-stimulated animals and prevented the action of raphe stimulation. The data indicate that the cerebral serotoninergic system might have an inhibitory control over the performance of conditioned avoidance reflex.",
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AU - Kovács, G.

AU - Telegdy, G.

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AB - Performance of an active avoidance (bench-jumping) reflex has been studied in rats during stimulation of the midbrain raphe nuclei. Raphe stimulation (10 cps, 0.2 msec, 2.5-5.0 V) inhibited the performance of the reflex. A serotonin receptor blocker (methysergide, 2.0 mg/kg IP) increased the reflex performance in non-stimulated animals and prevented the action of raphe stimulation. The data indicate that the cerebral serotoninergic system might have an inhibitory control over the performance of conditioned avoidance reflex.

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KW - Methysergide

KW - Midbrain raphe stimulation

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