Inhibitory control of GABAergic interneurons in the hippocampus

T. Freund, Attila I. Gulyás

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

Hippocampal GABAergic interneurons are responsible for controlling the output and efficacy of synaptic input of large principal cell populations and, thereby, determine the oscillatory discharge patterns and synaptic plasticity in the hippocampus. Single interneurons are able to prevent repetitive firing of postsynaptic pyramidal cells (R. Miles, K. Toth, A.I. Gulyas, N. Hajos, and T.F. Freund. Neuron, 16: 815-823, 1996), whereas on occasion a single pyramidal cell may be able to activate an interneuron under in vitro conditions (A.I. Gulyas, R. Miles, A. Sik, K. Toth, N. Tamamaki, and T.F. Freund. Nature (London), 366: 683-687, 1993). Inhibition is therefore extremely powerful. Transient suppression of interneuronal activity allows the precise timing and synchronization of inhibitory postsynaptic potentials arriving at principal cells. A rhythmic suppression or modulation of interneuron discharge may be brought about by input from at least two major sources: (i) from other local interneurons or (ii) from subcortical centers. Of the possible local sources, in the present review particular attention will be paid to GABAergic neurons specialized to innervate other interneurons. Subcortical pathways known to modulate specific inhibitory functions in the hippocampus, i.e., the GABAergic and cholinergic septohippocampal and the serotonergic raphe hippocampal pathways, will also be reviewed. Roles of these control mechanisms may include the generation of theta and higher frequency oscillations, and the selective removal of inhibition from the termination zone of specific excitatory afferents, thereby increasing their efficacy and (or) plasticity.

Original languageEnglish
Pages (from-to)479-487
Number of pages9
JournalCanadian Journal of Physiology and Pharmacology
Volume75
Issue number5
DOIs
Publication statusPublished - 1997

Fingerprint

Interneurons
Hippocampus
Pyramidal Cells
GABAergic Neurons
Inhibitory Postsynaptic Potentials
Neuronal Plasticity
Cholinergic Agents
Neurons
Population

Keywords

  • Acetylcholine
  • Disinhibition
  • Serotonin
  • Subcortical afferents
  • Synchronization

ASJC Scopus subject areas

  • Physiology
  • Pharmacology

Cite this

Inhibitory control of GABAergic interneurons in the hippocampus. / Freund, T.; Gulyás, Attila I.

In: Canadian Journal of Physiology and Pharmacology, Vol. 75, No. 5, 1997, p. 479-487.

Research output: Contribution to journalArticle

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