Inhibitory binding of adenosine diphosphoribosyl transferase to the DNA primer site of reverse transcriptase templates

Kalman G. Buki, P. Bauer, Ernest Kun

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Purified adenosine diphosphoribose transferase protein binds to RNA-DNA hybrid templates of reverse transcriptase at the DNA primer site and inhibits RT activity of HIV and MMu RTs. This action is prevented by auto-poly-ADP-ribosylation of the transferase but is reinduced by inhibitory ligands of the enzyme.

Original languageEnglish
Pages (from-to)496-503
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume180
Issue number2
DOIs
Publication statusPublished - Oct 31 1991

Fingerprint

DNA Primers
RNA-Directed DNA Polymerase
Transferases
Adenosine
Adenosine Diphosphate Ribose
Adenosine Diphosphate
HIV
RNA
Ligands
DNA
Enzymes
Proteins

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Inhibitory binding of adenosine diphosphoribosyl transferase to the DNA primer site of reverse transcriptase templates. / Buki, Kalman G.; Bauer, P.; Kun, Ernest.

In: Biochemical and Biophysical Research Communications, Vol. 180, No. 2, 31.10.1991, p. 496-503.

Research output: Contribution to journalArticle

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