Inhibitory binding of adenosine diphosphoribosyl transferase to the DNA primer site of reverse transcriptase templates

Kalman G. Buki, Pal I. Bauer, Ernest Kun

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5 Citations (Scopus)

Abstract

Purified adenosine diphosphoribose transferase protein binds to RNA-DNA hybrid templates of reverse transcriptase at the DNA primer site and inhibits RT activity of HIV and MMu RTs. This action is prevented by auto-poly-ADP-ribosylation of the transferase but is reinduced by inhibitory ligands of the enzyme.

Original languageEnglish
Pages (from-to)496-503
Number of pages8
JournalBiochemical and biophysical research communications
Volume180
Issue number2
DOIs
Publication statusPublished - Oct 31 1991

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ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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