Inhibitory action of midbrain raphe stimulation on stress-induced elevation of plasma corticosterone level in rats

Gábor L. Kovács, Judith Kishonti, Kálmán Lissák, Gyula Telegdy

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Electric stimulation of rat midbrain raphe nuclei by means of chronically implanted bipolar electrodes was able to reduce the stress-induced increase in plasma corticosterone level by about 40-50%. A serotonin receptor blocker, methysergide, prevented the stimulation-induced inhibition of the stress response. The results support the possible existence of serotoninergic inhibition of hypothalamo-pituitary-adrenocortical activation in rats.

Original languageEnglish
Pages (from-to)305-310
Number of pages6
JournalNeuroscience Letters
Issue number5-6
Publication statusPublished - Dec 1976


ASJC Scopus subject areas

  • Neuroscience(all)

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