Inhibitors of lipid peroxidation among new pyrimido[1',6':1,2]pyrido[3,4-b]indoles

G. Domany, A. Gere, M. Paroczai, C. S. Szantay, G. G. Ferenczy, I. Schon, B. Kiss, E. Karpati

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Abstract

A series of potent inhibitors of NADPH and Fe2+ dependent lipid peroxidation has been found among new pyrimido[1'6':1,2]pyrido[3,4-b]indole derivatives. According to preliminary structure-activity relationship analysis the saturated pyrimidine moiety was responsible for this effect. Some members of this family were effective in a bilateral carotid occlusion model in mice, and some derivatives showed protective effect in a mouse head injury model.

Original languageEnglish
Pages (from-to)806-810
Number of pages5
JournalPharmazie
Volume49
Issue number11
Publication statusPublished - Jan 1 1994

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ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Domany, G., Gere, A., Paroczai, M., Szantay, C. S., Ferenczy, G. G., Schon, I., Kiss, B., & Karpati, E. (1994). Inhibitors of lipid peroxidation among new pyrimido[1',6':1,2]pyrido[3,4-b]indoles. Pharmazie, 49(11), 806-810.