Inhibition of virus multiplication and alteration of cyclic AMP level in cell cultures by flavonoids

I. Mucsi, B. M. Prágai

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The inhibitory effect of four flavonoid compounds on virus multiplication and their influence on the intracellular cyclic AMP (cAMP) level were studied in cell cultures. Quercetin and quercitrin reduced the yields of Human (alpha) herpesvirus 1 (HSV-1) and Suid (alpha) herpesvirus 1 (pseudorabies virus), but hesperidin and rutin had no effect. Further, quercetin and quercitrin elevated the intracellular level of cAMP, whereas hesperidin and rutin did not alter the cAMP level. Both antiviral activity and cAMP-enhancing effect were dependent on the concentrations of the flavonoids, and these effects turned out to be parallel. This study suggests that a relation exists between the antiviral effect and the cAMP-enhancing activity of flavonoids.

Original languageEnglish
Pages (from-to)930-931
Number of pages2
JournalExperientia
Volume41
Issue number7
DOIs
Publication statusPublished - Jul 1985

Fingerprint

Viruses
Cell culture
Flavonoids
Cyclic AMP
Suid Herpesvirus 1
Cell Culture Techniques
Hesperidin
Rutin
Quercetin
Antiviral Agents
Human Herpesvirus 1
quercitrin

Keywords

  • cyclic AMP-enhancing activity
  • flavonoids
  • human (alpha) herpesvirus 1
  • Suid (alpha) herpesvirus 1

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Inhibition of virus multiplication and alteration of cyclic AMP level in cell cultures by flavonoids. / Mucsi, I.; Prágai, B. M.

In: Experientia, Vol. 41, No. 7, 07.1985, p. 930-931.

Research output: Contribution to journalArticle

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