Inhibition of the serine proteases of the complement system

P. Gál, J. Dobó, László Beinrohr, G. Pál, P. Závodszky

Research output: Chapter in Book/Report/Conference proceedingConference contribution

17 Citations (Scopus)

Abstract

Proteases play important roles in human physiology and pathology. The complement -system is a proteolytic cascade, where serine proteases activate each other by limited proteolysis in a strictly ordered manner. Serine proteases are essential in both the initiation and the amplification of the cascade. Since uncontrolled complement activation contributes to the development of serious disease conditions, inhibition of the complement serine proteases could be an attractive therapeutic approach. In this chapter, we give a brief overview of the major types of natural serine protease inhibitors and their role in controlling the complement cascade. A special emphasis is laid on C1-inhibitor, a natural complement protease inhibitor, which is approved for clinical use in hereditary angioedema (HAE). We also examine the potential of developing artificial complement protease inhibitors. Synthetic small-molecule drugs can be very efficient serine protease inhibitors, but they usually lack sufficient specificity. A promising approach to yield more specific compounds is the alteration of natural protease inhibitors through engineering or directed evolution resulting in new variants with fine-tuned specificity and enhanced affinity.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages23-40
Number of pages18
Volume734
ISBN (Print)9781461441175
DOIs
Publication statusPublished - 2013

Publication series

NameAdvances in Experimental Medicine and Biology
Volume734
ISSN (Print)00652598

Fingerprint

Complement Inactivating Agents
Serine Proteases
Protease Inhibitors
Serine Proteinase Inhibitors
Proteolysis
Hereditary Angioedemas
Complement Activation
Physiology
Pathology
Amplification
Peptide Hydrolases
Chemical activation
Molecules
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Gál, P., Dobó, J., Beinrohr, L., Pál, G., & Závodszky, P. (2013). Inhibition of the serine proteases of the complement system. In Advances in Experimental Medicine and Biology (Vol. 734, pp. 23-40). (Advances in Experimental Medicine and Biology; Vol. 734). Springer New York LLC. https://doi.org/10.1007/978-1-4614-4118-2_2

Inhibition of the serine proteases of the complement system. / Gál, P.; Dobó, J.; Beinrohr, László; Pál, G.; Závodszky, P.

Advances in Experimental Medicine and Biology. Vol. 734 Springer New York LLC, 2013. p. 23-40 (Advances in Experimental Medicine and Biology; Vol. 734).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Gál, P, Dobó, J, Beinrohr, L, Pál, G & Závodszky, P 2013, Inhibition of the serine proteases of the complement system. in Advances in Experimental Medicine and Biology. vol. 734, Advances in Experimental Medicine and Biology, vol. 734, Springer New York LLC, pp. 23-40. https://doi.org/10.1007/978-1-4614-4118-2_2
Gál P, Dobó J, Beinrohr L, Pál G, Závodszky P. Inhibition of the serine proteases of the complement system. In Advances in Experimental Medicine and Biology. Vol. 734. Springer New York LLC. 2013. p. 23-40. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-1-4614-4118-2_2
Gál, P. ; Dobó, J. ; Beinrohr, László ; Pál, G. ; Závodszky, P. / Inhibition of the serine proteases of the complement system. Advances in Experimental Medicine and Biology. Vol. 734 Springer New York LLC, 2013. pp. 23-40 (Advances in Experimental Medicine and Biology).
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