Similar to the atherosclerotic cardiovascular disease, primary and secondary renal diseases are also characterised by a "continuum". The "renal continuum" comprises the initial immunologic, metabolic or hemodynamic insult which, through progressive glomerular and interstitial renal damage, results in end stage renal failure. The rennin-angiotensin system plays a pivotal role in the progression of renal disease. We use diabetic nephropathy to demonstrate the clinical benefits that can be attained by administering inhibitors of the rennin-angiotensin system in more and more progressive stages of the diabetic "renal continuum". Evidence from clinical trials among diabetic patients attest to the notion that specific inhibition of the rennin-angiotensin system provides a benefit that is above what could be expected from the blood pressure lowering effects of these drugs alone.
|Translated title of the contribution||Inhibition of the renin-angiotensin system to prevent target organ damage: the "renal continuum"|
|Number of pages||4|
|Issue number||18 Suppl 1|
|Publication status||Published - May 4 2003|
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