Inhibition of the effects of LSD and p-bromo-methamphetamine (V-111) by p-chlorophenylalanine

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Abstract

The role of serotoninergic mechanisms in the effect of psychotomimetic drugs was investigated. Inhibition of the synthesis of serotonin by p-chloro-phenylalanine (p-CPA) markedly reduced behavioural effects of LSD, mescaline and p-bromo-methamphetamine (V-111) in rats and the pyrotogenic effect of LSD and V-111 in rabbits. Blockade of tyrosine hydroxylase activity by α-methyl-p-tyrosine (α-MPT) failed to influence the behavioural effects of the psychotomimetics studied.

Original languageEnglish
Pages (from-to)67-70
Number of pages4
JournalPharmacological Research Communications
Volume2
Issue number1
DOIs
Publication statusPublished - Mar 1970

ASJC Scopus subject areas

  • Pharmacology

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