Inhibition of the adhesion of E. coli on cultured human epithelial cells in the presence of promethazine or imipramine

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Abstract

The adhesion and multiplication of E.coli strain K12 with a derepressed synthesis of sex pili and of a nephropathogenic E.coli strain isolated from the urine of a patient with pyelonephritis, were demonstrated on the surface of cultured HEp-2 cells. The adhesion of the two E.coli strains was inhibited in the presence of 0.5-5.0 μg/ml promethazine or imipramine, but the multiplication of the bacteria on the monolayers was not decreased significantly in the presence of the two drugs. A scanning electromicroscopic technique was developed to study bacterial adhesion and colony formation on epithelial cells.

Original languageEnglish
Pages (from-to)388-396
Number of pages9
JournalZentralblatt fur Bakteriologie Mikrobiologie und Hygiene - Abt. 1 Orig. A
Volume254
Issue number3
Publication statusPublished - 1983

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Promethazine
Imipramine
Sex Pilus
Epithelial Cells
Escherichia coli
Bacterial Adhesion
Escherichia coli K12
Pyelonephritis
Urine
Bacteria
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Immunology

Cite this

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abstract = "The adhesion and multiplication of E.coli strain K12 with a derepressed synthesis of sex pili and of a nephropathogenic E.coli strain isolated from the urine of a patient with pyelonephritis, were demonstrated on the surface of cultured HEp-2 cells. The adhesion of the two E.coli strains was inhibited in the presence of 0.5-5.0 μg/ml promethazine or imipramine, but the multiplication of the bacteria on the monolayers was not decreased significantly in the presence of the two drugs. A scanning electromicroscopic technique was developed to study bacterial adhesion and colony formation on epithelial cells.",
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AU - Molnár, J.

AU - Mucsi, I.

AU - Kasa, P.

PY - 1983

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N2 - The adhesion and multiplication of E.coli strain K12 with a derepressed synthesis of sex pili and of a nephropathogenic E.coli strain isolated from the urine of a patient with pyelonephritis, were demonstrated on the surface of cultured HEp-2 cells. The adhesion of the two E.coli strains was inhibited in the presence of 0.5-5.0 μg/ml promethazine or imipramine, but the multiplication of the bacteria on the monolayers was not decreased significantly in the presence of the two drugs. A scanning electromicroscopic technique was developed to study bacterial adhesion and colony formation on epithelial cells.

AB - The adhesion and multiplication of E.coli strain K12 with a derepressed synthesis of sex pili and of a nephropathogenic E.coli strain isolated from the urine of a patient with pyelonephritis, were demonstrated on the surface of cultured HEp-2 cells. The adhesion of the two E.coli strains was inhibited in the presence of 0.5-5.0 μg/ml promethazine or imipramine, but the multiplication of the bacteria on the monolayers was not decreased significantly in the presence of the two drugs. A scanning electromicroscopic technique was developed to study bacterial adhesion and colony formation on epithelial cells.

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