Inhibition of potassium-induced release of histamine from mast cells by tetraethylammonium and tetramethylammonium

A. Németh, P. Magyar, Z. Huszti

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Abstract

In accordance with our previous results, a marked release of histamine (HA) from rat peritoneal mast cells was initiated by 150 m M KCl in the absence of extracellular Ca2+. This release could be reduced by 20-60 m M tetraethylammonium (TEA) or tetramethylammonium (TMA), the non-selective K+-channel blockers, Ouabain, the general inhibitor of (Na++K+) ATP-ase, failed to produce any changes in this release. The action of TEA discriminated between the initiation of HA release evoked by different agents, producing a blockade of the K+-induced but not the 48/80-stimulated HA release. In total, these data suggest the presence of TEA/TMA-sensitive K+-channels in the mast cell membrane and their involvement in one of the possible pathways for the initiation of HA release.

Original languageEnglish
Pages (from-to)143-145
Number of pages3
JournalAgents and Actions
Volume30
Issue number1-2
DOIs
Publication statusPublished - Apr 1 1990

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ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)

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