Inhibition of neurotransmission by angiotensin I and II in rabbit isolated ear artery

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Angiotensin I and II inhibited the nerve stimulation-induced pressure changes in isolated, perfused rabbit ear atery with an IC50 of 3.07 and 0.36 nM, respectively. Neither angiotensin I nor angiotensin II affected the basal pressure or the pressure changes elicited by exogenously administered norepinephrine (NE). The potency of angiotensin I was unaltered by 10-5 M captopril, indicating that conversion by angiotensin converting enzyme (ACE) was not necessary and did not take place. [Sar1, Val5, Ala8]angiotensin II (3 × 10-8 M) antagonized the effect of angiotensin I. These findings could have implications regarding ACE inhibitor therapy and the pathophysiology of migraine.

Original languageEnglish
Pages (from-to)281-286
Number of pages6
JournalEuropean Journal of Pharmacology
Volume179
Issue number3
DOIs
Publication statusPublished - Apr 25 1990

Fingerprint

Angiotensin I
Synaptic Transmission
Angiotensin II
Ear
Arteries
Rabbits
Pressure
Saralasin
Enzyme Therapy
Captopril
Peptidyl-Dipeptidase A
Migraine Disorders
Angiotensin-Converting Enzyme Inhibitors
Inhibitory Concentration 50
Norepinephrine

Keywords

  • Angiotensin I
  • Angiotensin II
  • Captopril
  • Ear artery (rabbit, isolated)
  • Neurotransmission (inhibition of)
  • [Sar, Val, Ala]angiotensin II

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Inhibition of neurotransmission by angiotensin I and II in rabbit isolated ear artery. / Rónai, A.

In: European Journal of Pharmacology, Vol. 179, No. 3, 25.04.1990, p. 281-286.

Research output: Contribution to journalArticle

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