Inhibition of neuronal nitric oxide synthase protects against MPTP toxicity

Peter Klivenyi, Ole A. Andreassen, Robert J. Ferrante, Eric Lancelot, David Reif, M. Flint Beal

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58 Citations (Scopus)

Abstract

Previous work showed that several relatively specific inhibitors of neuronal nitric oxide synthase (nNOS) produce protection against MPTP induced dopaminergic toxicity. We examined whether a highly specific novel inhibitor of nNOS, ARR1 7338, could also protect against MPTP toxicity. ARR17338 produced dose-dependent significant protection against MPTP induced depletion of dopamine and protected against MPTP induced depletions of tyrosine hydroxylase immunostained neurons in the substantia nigra. These results provide further evidence that inhibitors of nNOS may be useful for the treatment of Parkinson's disease. (C) 2000 Lippincott Williams and Wilkins.

Original languageEnglish
Pages (from-to)1265-1268
Number of pages4
JournalNeuroreport
Volume11
Issue number6
DOIs
Publication statusPublished - Apr 27 2000

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Keywords

  • MPTP
  • Nitric oxide
  • Peroxynitrite, Parkinson's disease

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Klivenyi, P., Andreassen, O. A., Ferrante, R. J., Lancelot, E., Reif, D., & Beal, M. F. (2000). Inhibition of neuronal nitric oxide synthase protects against MPTP toxicity. Neuroreport, 11(6), 1265-1268. https://doi.org/10.1097/00001756-200004270-00024