Inhibition of mouse spleen cell rosette formation by cobalt irradiation

measurement of the immunosuppressive effect of gamma radiation

B. Fekete, G. Szegedi, J. Petranyi, P. Gergely, G. Szabó, Z. Dézsi

Research output: Contribution to journalArticle

Abstract

Total body cobalt irradiation of Balb/c mice with a dose of 1/5LD50 proved to inhibit immune rosette formation. The irradiation reduced the number of rosette forming cells and suppressed the rosette forming capacity of the remaining lymphocyte population. T lymphocytes were particularly sensitive to the irradiation. When irradiation was given before the antigen or on the day of its administration, suppression of rosette formation was more marked than with irradiation following the antigenic stimulus. The results provide additional information on the immunocyte suppressive activity of ionizing radiation.

Original languageEnglish
Pages (from-to)277-282
Number of pages6
JournalActa Medica Academiae Scientiarum Hungaricae
Volume30
Issue number4
Publication statusPublished - 1973

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Rosette Formation
Gamma Rays
Immunosuppressive Agents
Cobalt
Spleen
Whole-Body Irradiation
Ionizing Radiation
Lymphocytes
T-Lymphocytes
Antigens
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Inhibition of mouse spleen cell rosette formation by cobalt irradiation : measurement of the immunosuppressive effect of gamma radiation. / Fekete, B.; Szegedi, G.; Petranyi, J.; Gergely, P.; Szabó, G.; Dézsi, Z.

In: Acta Medica Academiae Scientiarum Hungaricae, Vol. 30, No. 4, 1973, p. 277-282.

Research output: Contribution to journalArticle

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