Inhibition of Mg2+Na+K+-dependent ATPase system from human gastric mucosa by prostaglandins E1 and E2

G. Mózsik, J. Kutas, L. Nagy, G. Németh

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The Mg2+-dependent and Na+K+-dependent (Na+K+-activated or transport) ATPase (EC 3.6.1.3.) were prepared from human fundic gastric mucosa and the effects of prostaglandins E1 and E2 on their activity studied. Significant inhibitions of Mg2+-dependent, total (Mg2+-dependent and Na+K+-dependent) and Na+K+-dependent ATPase activities were caused by prostaglandins E1 and E2, in concentrations of 10-9 to 10 -6 M. A possible role of Mg2+Na+K+-dependent ATPase system is discussed in the inhibition of gastric secretion by type E prostaglandins.

Original languageEnglish
Pages (from-to)133-137
Number of pages5
JournalEuropean Journal of Pharmacology
Volume29
Issue number1
DOIs
Publication statusPublished - Nov 1974

Keywords

  • ATP-ADP system of cells
  • Adenyl cyclase
  • Human gastric mucosa
  • Inhibition of gastric secretion
  • Membrane ATPase system
  • Prostaglandin E
  • Prostaglandin E

ASJC Scopus subject areas

  • Pharmacology

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