Inhibition of lipid peroxidation by dihydroquinoline-type antioxidant (CH 402)

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9 Citations (Scopus)

Abstract

The in vitro effect of a non-toxic, water soluble, low molecular weight, stable dihydroquinoline-type antioxidant, CH 402 (Na (2,2-dimethyl-1,2-dihydroquinoline-4-yl) - methane sulphonic acid) was studied on free radical reactions in brain subcellular fractions. Experiments were performed using rat and mouse brain homogenate and microsomal fractions. Non ... enzymatically induced lipid peroxidation by ascorbic acid was studied in correlation with ascorbic acid and CH 402 concentrations and incubation time. Malondialdehyde production during lipid peroxidation was measured by the thiobarbituric acid test. In a concentration range of 10-2-10-5 M CH 402 dose - dependently inhibited the ascorbic acid induced in vitro lipid peroxidation in mouse and rat brain subcellular fractions.

Original languageEnglish
Pages (from-to)409-413
Number of pages5
JournalFree Radical Research
Volume4
Issue number6
DOIs
Publication statusPublished - 1988

Fingerprint

Lipid Peroxidation
Ascorbic Acid
Brain
Subcellular Fractions
Antioxidants
Lipids
Rats
Free radical reactions
Sulfonic Acids
Methane
Malondialdehyde
Free Radicals
Molecular Weight
Molecular weight
Water
CH 402
Experiments
In Vitro Techniques
thiobarbituric acid

Keywords

  • Brain microsomes
  • Dihydroquinoline type antioxidant
  • Free radicals
  • Lipid peroxidation

ASJC Scopus subject areas

  • Biochemistry

Cite this

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abstract = "The in vitro effect of a non-toxic, water soluble, low molecular weight, stable dihydroquinoline-type antioxidant, CH 402 (Na (2,2-dimethyl-1,2-dihydroquinoline-4-yl) - methane sulphonic acid) was studied on free radical reactions in brain subcellular fractions. Experiments were performed using rat and mouse brain homogenate and microsomal fractions. Non ... enzymatically induced lipid peroxidation by ascorbic acid was studied in correlation with ascorbic acid and CH 402 concentrations and incubation time. Malondialdehyde production during lipid peroxidation was measured by the thiobarbituric acid test. In a concentration range of 10-2-10-5 M CH 402 dose - dependently inhibited the ascorbic acid induced in vitro lipid peroxidation in mouse and rat brain subcellular fractions.",
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author = "A. Bl{\'a}zovics and A. Somogyi and G. Lengyel and I. L{\'a}ng and J. Feh{\'e}r",
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T1 - Inhibition of lipid peroxidation by dihydroquinoline-type antioxidant (CH 402)

AU - Blázovics, A.

AU - Somogyi, A.

AU - Lengyel, G.

AU - Láng, I.

AU - Fehér, J.

PY - 1988

Y1 - 1988

N2 - The in vitro effect of a non-toxic, water soluble, low molecular weight, stable dihydroquinoline-type antioxidant, CH 402 (Na (2,2-dimethyl-1,2-dihydroquinoline-4-yl) - methane sulphonic acid) was studied on free radical reactions in brain subcellular fractions. Experiments were performed using rat and mouse brain homogenate and microsomal fractions. Non ... enzymatically induced lipid peroxidation by ascorbic acid was studied in correlation with ascorbic acid and CH 402 concentrations and incubation time. Malondialdehyde production during lipid peroxidation was measured by the thiobarbituric acid test. In a concentration range of 10-2-10-5 M CH 402 dose - dependently inhibited the ascorbic acid induced in vitro lipid peroxidation in mouse and rat brain subcellular fractions.

AB - The in vitro effect of a non-toxic, water soluble, low molecular weight, stable dihydroquinoline-type antioxidant, CH 402 (Na (2,2-dimethyl-1,2-dihydroquinoline-4-yl) - methane sulphonic acid) was studied on free radical reactions in brain subcellular fractions. Experiments were performed using rat and mouse brain homogenate and microsomal fractions. Non ... enzymatically induced lipid peroxidation by ascorbic acid was studied in correlation with ascorbic acid and CH 402 concentrations and incubation time. Malondialdehyde production during lipid peroxidation was measured by the thiobarbituric acid test. In a concentration range of 10-2-10-5 M CH 402 dose - dependently inhibited the ascorbic acid induced in vitro lipid peroxidation in mouse and rat brain subcellular fractions.

KW - Brain microsomes

KW - Dihydroquinoline type antioxidant

KW - Free radicals

KW - Lipid peroxidation

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