Inhibition of lipid peroxidation by dihydroquinoline-type antioxidant (CH 402)

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Abstract

The in vitro effect of a non-toxic, water soluble, low molecular weight, stable dihydroquinoline-type antioxidant, CH 402 (Na (2,2-dimethyl-1,2-dihydroquinoline-4-yl) - methane sulphonic acid) was studied on free radical reactions in brain subcellular fractions. Experiments were performed using rat and mouse brain homogenate and microsomal fractions. Non ... enzymatically induced lipid peroxidation by ascorbic acid was studied in correlation with ascorbic acid and CH 402 concentrations and incubation time. Malondialdehyde production during lipid peroxidation was measured by the thiobarbituric acid test. In a concentration range of 10-2-10-5 M CH 402 dose - dependently inhibited the ascorbic acid induced in vitro lipid peroxidation in mouse and rat brain subcellular fractions.

Original languageEnglish
Pages (from-to)409-413
Number of pages5
JournalFree radical research
Volume4
Issue number6
DOIs
Publication statusPublished - Jan 1 1988

Keywords

  • Brain microsomes
  • Dihydroquinoline type antioxidant
  • Free radicals
  • Lipid peroxidation

ASJC Scopus subject areas

  • Biochemistry

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