Inhibition of immunospecific rosette formation for the study of two prednisolone derivatives

B. Fekete, G. Szegedi, P. Gergely, G. Szabó, G. Petrányi

Research output: Contribution to journalArticle

Abstract

Methyl piperazinyl prednisolone and prednisolone succinate have been compared for their immunosuppressive effect by means of the rosette inhibition test. The procedure based on the inhibition in vivo of immunospecific rosette formation has been found more suitable for this purpose than in vitro inhibition. Rosette formation was inhibited more intensively by massive doses of prednisolone succinate than by its derivative. With reduced doses, the difference between the two compounds tended to diminish.

Original languageEnglish
Pages (from-to)327-330
Number of pages4
JournalActa medica Academiae Scientiarum Hungaricae
Volume29
Issue number3-4
Publication statusPublished - Dec 1 1972

ASJC Scopus subject areas

  • Medicine(all)

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