Methyl piperazinyl prednisolone and prednisolone succinate have been compared for their immunosuppressive effect by means of the rosette inhibition test. The procedure based on the inhibition in vivo of immunospecific rosette formation has been found more suitable for this purpose than in vitro inhibition. Rosette formation was inhibited more intensively by massive doses of prednisolone succinate than by its derivative. With reduced doses, the difference between the two compounds tended to diminish.
|Number of pages||4|
|Journal||Acta medica Academiae Scientiarum Hungaricae|
|Publication status||Published - Dec 1 1972|
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