Inhibition of human cytomegalovirus IE gene expression by dihydro-β-agarofuran sesquiterpenes isolated from Euonymus species

Rozália Pusztai, J. Hohmann, D. Rédei, Helga Engi, J. Molnár

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The development of strategies intended to inhibit human cytomegalovirus (HCMV) immediate-early (IE) antigen expression is an important goal in research designed to prevent and treat certain forms of cancer. The aim of this study was to identify potent IE antigen-targeting natural compounds as antitumor promoters in an in vitro model of tumor promotion. Nineteen dihydro-β-agarofuran sesquiterpenes isolated from Euonymus species were evaluated for their abiliiy to inhibit HCMV IE antigen expression in human lung adenocarcinoma (A549) cells. Five esters of penta- and hexahydroxydihydro-β-agarofuran proved to be active components in these Euonymus species, inhibiting the IE antigen expression of HCMV. The highest activity was displayed by 2β,6α,15-triacetoxy-1β-benzoyloxy-9α- nicotinoyloxydihydro-β- agarofuran. These effective compounds may be regarded as prototypes of antitumor promoters, as secondary chemopreventive agents which can modify or halt tumor promotion in general.

Original languageEnglish
Pages (from-to)787-792
Number of pages6
JournalIn Vivo
Volume22
Issue number6
Publication statusPublished - Nov 2008

Fingerprint

Euonymus
Immediate-Early Genes
Sesquiterpenes
Cytomegalovirus
Gene expression
Gene Expression
Antigens
Tumors
Neoplasms
Rubiaceae
Esters
Research

Keywords

  • Antitumor promotion
  • Cytomegalovirus
  • Dihydro-β-agarofuran
  • Euonymus species
  • IE antigen expression
  • Sesquiterpene

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

Cite this

Inhibition of human cytomegalovirus IE gene expression by dihydro-β-agarofuran sesquiterpenes isolated from Euonymus species. / Pusztai, Rozália; Hohmann, J.; Rédei, D.; Engi, Helga; Molnár, J.

In: In Vivo, Vol. 22, No. 6, 11.2008, p. 787-792.

Research output: Contribution to journalArticle

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