Inhibition of hiv infection of H9 cells by chlorpromazine derivatives

Indira Hewlett, Sherwin Lee, Jozsef Molnar, Sandor Foldeak, P. Scott Pine, James L. Weaver, Adorjan Aszalos

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The binding between the HIV surface protein, gp120, and the CD4 coreceptor is known to be initiated by electrostatic interactions. Because of the ability of chlorpromazine to interact with proteins by charge transfer, we tested several derivatives for their ability to block binding of HIV to CD4+ cells. We have shown that 7,8-dioxo-chlorpromazine blocks binding of fluorescein isothiocyanate-labeled antiLeu3a and rgp120 to peripheral human blood T4 cells and blocks syncytia formation between gp120- and CD4- expressing cells. We also found that 7.8-dioxo-chlorpromazine blocks HIV infectivity of H9 cells and acts synergistically with zidovudine.

Original languageEnglish
Pages (from-to)16-20
Number of pages5
JournalJournal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Volume15
Issue number1
DOIs
Publication statusPublished - May 1 1997

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Keywords

  • Anti-Leu3a binding
  • Dioxo- chlorpromazine
  • HIV infectivity
  • Syncytia formation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Virology

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