Inhibition of high-affinity synaptosomal uptake of γ-aminobutyric acid by a bicyclo-heptane derivative

I. Kovacs, G. Maksay, M. Simonyi

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

EGYT 3886 (dia(-)2-phenyl-2-(dimethylaminoethoxy) - 1R - 1,7,7-trimethyl-bicyclo[2.2.1]heptane hemifumarate) exhibiting anxiolytic and anticonvulsant properties is inactive on various binding sites of the GABA(A) (γ-aminobutyric acid A) receptor/chloride ionophore complex, but is an effective inhibitor of high-affinity synaptosomal 3H-GABA uptake.

Original languageEnglish
Pages (from-to)295-297
Number of pages3
JournalArzneimittel-Forschung/Drug Research
Volume39
Issue number3
Publication statusPublished - Jan 1 1989

ASJC Scopus subject areas

  • Drug Discovery

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