Inhibition of haloperidol-induced catalepsy by cholecystokinin octapeptides after central administration to rats

T. Kádár, B. Penke, K. Kovács, G. Telegdy

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The possible cataleptogenic or antlcataleptic effects of cholecystokinin octapeptide sulphate ester (CCK-8-SE) and desulphated CCK-8 (CCK-8-NS) were evaluated in rats after intracerebroventricular (i.c.v.) administration. Neither CCK-8-SE nor CCK-8-NS induced any sign of catalepsy. When haloperidol, in a dose od 1.o mg/kg (i.p.), and either CCK-8-SE or CCK-8-NS, in doses of 8, 80 or 800 pmol (i.c.v.), were applied at the same time, the peptides significantly decreased the total duration of catalepsy, the 80 pmol dose being the most effective. For the inhibition of catalepsy CCK-8-NS was the more active as it decreased catalepsy scores even 120 min after administration. Both peptides showed only transient effects on the fully developed catalepsy induced by haloperidol.

Original languageEnglish
Pages (from-to)577-580
Number of pages4
JournalNeuropharmacology
Volume24
Issue number6
DOIs
Publication statusPublished - 1985

Fingerprint

Catalepsy
Sincalide
Haloperidol
Peptides
Esters

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Drug Discovery
  • Pharmacology

Cite this

Inhibition of haloperidol-induced catalepsy by cholecystokinin octapeptides after central administration to rats. / Kádár, T.; Penke, B.; Kovács, K.; Telegdy, G.

In: Neuropharmacology, Vol. 24, No. 6, 1985, p. 577-580.

Research output: Contribution to journalArticle

@article{d3a05e9b42e54a128057c77386d7490c,
title = "Inhibition of haloperidol-induced catalepsy by cholecystokinin octapeptides after central administration to rats",
abstract = "The possible cataleptogenic or antlcataleptic effects of cholecystokinin octapeptide sulphate ester (CCK-8-SE) and desulphated CCK-8 (CCK-8-NS) were evaluated in rats after intracerebroventricular (i.c.v.) administration. Neither CCK-8-SE nor CCK-8-NS induced any sign of catalepsy. When haloperidol, in a dose od 1.o mg/kg (i.p.), and either CCK-8-SE or CCK-8-NS, in doses of 8, 80 or 800 pmol (i.c.v.), were applied at the same time, the peptides significantly decreased the total duration of catalepsy, the 80 pmol dose being the most effective. For the inhibition of catalepsy CCK-8-NS was the more active as it decreased catalepsy scores even 120 min after administration. Both peptides showed only transient effects on the fully developed catalepsy induced by haloperidol.",
author = "T. K{\'a}d{\'a}r and B. Penke and K. Kov{\'a}cs and G. Telegdy",
year = "1985",
doi = "10.1016/0028-3908(85)90067-X",
language = "English",
volume = "24",
pages = "577--580",
journal = "Neuropharmacology",
issn = "0028-3908",
publisher = "Elsevier Limited",
number = "6",

}

TY - JOUR

T1 - Inhibition of haloperidol-induced catalepsy by cholecystokinin octapeptides after central administration to rats

AU - Kádár, T.

AU - Penke, B.

AU - Kovács, K.

AU - Telegdy, G.

PY - 1985

Y1 - 1985

N2 - The possible cataleptogenic or antlcataleptic effects of cholecystokinin octapeptide sulphate ester (CCK-8-SE) and desulphated CCK-8 (CCK-8-NS) were evaluated in rats after intracerebroventricular (i.c.v.) administration. Neither CCK-8-SE nor CCK-8-NS induced any sign of catalepsy. When haloperidol, in a dose od 1.o mg/kg (i.p.), and either CCK-8-SE or CCK-8-NS, in doses of 8, 80 or 800 pmol (i.c.v.), were applied at the same time, the peptides significantly decreased the total duration of catalepsy, the 80 pmol dose being the most effective. For the inhibition of catalepsy CCK-8-NS was the more active as it decreased catalepsy scores even 120 min after administration. Both peptides showed only transient effects on the fully developed catalepsy induced by haloperidol.

AB - The possible cataleptogenic or antlcataleptic effects of cholecystokinin octapeptide sulphate ester (CCK-8-SE) and desulphated CCK-8 (CCK-8-NS) were evaluated in rats after intracerebroventricular (i.c.v.) administration. Neither CCK-8-SE nor CCK-8-NS induced any sign of catalepsy. When haloperidol, in a dose od 1.o mg/kg (i.p.), and either CCK-8-SE or CCK-8-NS, in doses of 8, 80 or 800 pmol (i.c.v.), were applied at the same time, the peptides significantly decreased the total duration of catalepsy, the 80 pmol dose being the most effective. For the inhibition of catalepsy CCK-8-NS was the more active as it decreased catalepsy scores even 120 min after administration. Both peptides showed only transient effects on the fully developed catalepsy induced by haloperidol.

UR - http://www.scopus.com/inward/record.url?scp=0021838355&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021838355&partnerID=8YFLogxK

U2 - 10.1016/0028-3908(85)90067-X

DO - 10.1016/0028-3908(85)90067-X

M3 - Article

C2 - 2862602

AN - SCOPUS:0021838355

VL - 24

SP - 577

EP - 580

JO - Neuropharmacology

JF - Neuropharmacology

SN - 0028-3908

IS - 6

ER -