Inhibition of gluconeogenesis, ureogenesis and drug oxidation by redox cycler quinone in isolated mouse hepatocytes

Gyöngyi Galántai, Tamás Garzó, Ferenc Antoni, József Mandl, Gábor Bánhegyi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

1. 1. The effect of a redox cycler and arylator (menadione) and a pure arylator quinone (benzoquinone) was studied on different NADPH generating and consuming processes in isolated mouse hepatocytes. 2. 2. Menadione inhibited gluconeogenesis from alanine but not from fructose or glycerol. 3. 3. Drug oxidation measured as aniline hydroxylation and aminopyrine N-demethylation could be inhibited by menadione in microsomal membrane and in isolated hepatocytes both from fed or fasted animals. 4. 4. Ureogenesis in isolated hepatocytes from fed mice could not be inhibited even by high concentration of menadione, while in cells from fasted animals menadione was inhibitory at high concentration in the presence of gluconeogenic precursor and at lower concentration in the absence of it. 5. 5. Benzoquinone did not inhibit the above mentioned processes.

Original languageEnglish
Pages (from-to)999-1002
Number of pages4
JournalInternational Journal of Biochemistry
Volume24
Issue number6
DOIs
Publication statusPublished - Jun 1992

ASJC Scopus subject areas

  • Biochemistry

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