Inhibition of gastric emptying and small intestinal transit by ethanol is mediated by capsaicin-sensitive afferent nerves

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Abstract

The neural mechanisms involved in mediation of the inhibitory effects of ethanol on the gastric emptying and the small intestinal transit were studied in adult male rats. The gastrointestinal transit was determined by mea- suring the amount of phenol red recovered from the stom- ach and small intestine after intragastric administration. Spinal and/or vagal peptidergic afferent nerves were sub- jected to selective denervation by chemodenervation tech- niques using capsaicin, a potent and specific sensory neu- rotoxin. Intragastric administration of a 2.5 g/kg body weight dose of ethanol resulted in inhibition of the gastric empty- ing and the small intestinal transit. Prior systemic treat- ment with capsaicin, which defunctionalizes both spinal and vagal capsaicin-sensitive afferent nerves, abolished the inhibitory effect of ethanol on the gastrointestinal transit. Similarly, selective chemodenervation of the vagal afferents by perineural capsaicin treatment completely blocked the effect of ethanol. These observations furnish evidence indicative of the involvement of capsaicin-sensitive neural pathways, and in particular vagal afferent nerves, in the mediation of the inhibitory effect of large doses of ethanol on the gastrointestinal motility.

Original languageEnglish
Pages (from-to)17-21
Number of pages5
JournalNaunyn-Schmiedeberg's Archives of Pharmacology
Volume365
Issue number1
DOIs
Publication statusPublished - 2002

Fingerprint

Gastric Emptying
Capsaicin
Ethanol
Gastrointestinal Transit
Nerve Block
Phenolsulfonphthalein
Neural Pathways
Gastrointestinal Motility
Neurotoxins
Denervation
Small Intestine
Stomach
Body Weight

Keywords

  • Capsaicin-sensitive afferent nerves
  • Ethanol
  • Gastric emptying
  • Small intestinal transit
  • Vagus nerve

ASJC Scopus subject areas

  • Pharmacology

Cite this

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abstract = "The neural mechanisms involved in mediation of the inhibitory effects of ethanol on the gastric emptying and the small intestinal transit were studied in adult male rats. The gastrointestinal transit was determined by mea- suring the amount of phenol red recovered from the stom- ach and small intestine after intragastric administration. Spinal and/or vagal peptidergic afferent nerves were sub- jected to selective denervation by chemodenervation tech- niques using capsaicin, a potent and specific sensory neu- rotoxin. Intragastric administration of a 2.5 g/kg body weight dose of ethanol resulted in inhibition of the gastric empty- ing and the small intestinal transit. Prior systemic treat- ment with capsaicin, which defunctionalizes both spinal and vagal capsaicin-sensitive afferent nerves, abolished the inhibitory effect of ethanol on the gastrointestinal transit. Similarly, selective chemodenervation of the vagal afferents by perineural capsaicin treatment completely blocked the effect of ethanol. These observations furnish evidence indicative of the involvement of capsaicin-sensitive neural pathways, and in particular vagal afferent nerves, in the mediation of the inhibitory effect of large doses of ethanol on the gastrointestinal motility.",
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