Inhibition of feeding by the C-terminal tetrapeptide fragment of cholecystokinin in a novel environment

Tibor Kádár, B. Penke, Kálmán Kovács, G. Telegdy

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Several doses of the C-terminal tetrapeptide fragment of cholecystokinin octapeptide (CCK-5-8) were injected intraperitoneally (ip.) and intracerebroventricularly (icv.), and their effects on the feeding of 24-hr food-deprived rats in familiar and novel environments were studied. In the familiar environment, CCK-5-8 ip. or icv. had no effect on the food intake of the rats. In the novel environment (i.e. in an open field), CCK-5-8 showed merely slight effects on the main open-field parameters: only ip. administered CCK-5-8 enhanced the incidence of grooming. Of the feeding parameters tested in the open field, mainly the food intake/approach to food ratio was depressed by CCK-5-8 ip. or icv. The 24 μmole/kg ip. dose of CCK-5-8 decreased the food intake, while the 8 pmole icv. dose increased the number of approaches to food. After the treatments found to be the most effective, the latency to first bite was also enhanced. The results suggest that CCK-5-8 can amplify the arousal enhancement elicited by novelty through a central mechanism.

Original languageEnglish
Pages (from-to)97-108
Number of pages12
JournalNeuropeptides
Volume7
Issue number2
DOIs
Publication statusPublished - 1986

Fingerprint

Tetragastrin
Sincalide
Cholecystokinin
Eating
Rats
Food
Grooming
Inhibition (Psychology)
cholecystokinin pentapeptide
Bites and Stings
Arousal

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Clinical Neurology
  • Neuroscience(all)
  • Cellular and Molecular Neuroscience

Cite this

Inhibition of feeding by the C-terminal tetrapeptide fragment of cholecystokinin in a novel environment. / Kádár, Tibor; Penke, B.; Kovács, Kálmán; Telegdy, G.

In: Neuropeptides, Vol. 7, No. 2, 1986, p. 97-108.

Research output: Contribution to journalArticle

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