Inhibition of the esterase and amidase activities of bovine α- and β-thrombin in the presence of antithrombin III and heparin has been studied. It was found that both the esterase and amidase activities of α-thrombin were inhibited by antithrombin III and the reactions were accelerated by heparin. The inhibition of amidase and esterase activities of β-thrombin by antithrombin III has also been demonstrated. Heparin however did not increase the rate of inactivation of the enzyme.
- Antithrombin III
ASJC Scopus subject areas