Inhibition of esterase and amidase activities of α- and β-thrombin in the presence of antithrombin III and heparin

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Abstract

Inhibition of the esterase and amidase activities of bovine α- and β-thrombin in the presence of antithrombin III and heparin has been studied. It was found that both the esterase and amidase activities of α-thrombin were inhibited by antithrombin III and the reactions were accelerated by heparin. The inhibition of amidase and esterase activities of β-thrombin by antithrombin III has also been demonstrated. Heparin however did not increase the rate of inactivation of the enzyme.

Original languageEnglish
Pages (from-to)385-389
Number of pages5
JournalBBA - Enzymology
Volume566
Issue number2
DOIs
Publication statusPublished - Feb 9 1979

Keywords

  • Amidase
  • Antithrombin III
  • Esterase
  • Heparin
  • Thrombin

ASJC Scopus subject areas

  • Medicine(all)

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