Inhibition of anaphylactic shock by gadolinium chloride-induced Kupffer cell blockade

G. Lázár, G. Lázár, J. Kaszaki, J. Oláh, I. Kiss, E. Husztik

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Data in the literature concerning the role of macrophages in anaphylaxis are contradictory. In the present study, the effect of macrophage blockade induced by gadolinium chloride (GdCl3) on anaphylactic shock is investigated. Our observations show that GdCl3 prevents lethal anaphylactic shock in mice sensitized to ovalbumin. Gadolinium chloride given i.v. in a dose of 1 mg/100 g body weight 24 or 48 h before the elicitation of anaphylactic shock resulted in 80% survival, compared with the 43% survival in the control group. The same dose of this rare-earth metal salt also greatly reduced the mortality in mice sensitized with ovalbumin containing Bordetella pertussis vaccine, and similarly abrogated the symptoms of anaphylaxis, including the accumulation of serotonin and histamine in the liver. The results suggest that macrophages play an important role in mouse anaphylaxis.

Original languageEnglish
Pages (from-to)C97-C98
JournalAgents and Actions
Volume41
Issue number1 Supplement
DOIs
Publication statusPublished - Jun 1 1994

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)

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