Inhibition of adrenergic neurotransmission by prostaglandin E1 (PGE1) in the rabbit ear artery

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Abstract

Isolated central ear arteries of rabbits were perfused with Krebs solution at a constant flow rate of 2-7 ml/min. Pressure changes to periarterial nerve stimulation (1, 3, 10 and 30 Hz; 5-32 pulses) and to noradrenaline were measured in the presence and absence of prostaglandin E1 (PGE1). This substance in concentrations of 7 × 10-9- 4.5 × 10-7 produced a dose-dependent inhibition of constrictor responses to nerve stimulation. The degree of inhibitory action of PGE1 became progressively less as the frequency or length of stimulation was increased. Prostaglandin E1 (1.1 × 10-7 M) failed to affect the constrictor responses to noradrenaline and it markedly reduced the stimulation-evoked release of radioactivity from arteries incubated with [3]noradrenaline. The results indicate that PGE1 inhibits the vasoconstrictor responses of rabbit ear artery to nerve stimulation by reducing the release of the adrenergic transmitter.

Original languageEnglish
Pages (from-to)245-250
Number of pages6
JournalNeuropharmacology
Volume15
Issue number4
DOIs
Publication statusPublished - Apr 1976

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

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