Inhibition by deprenyl of dopamine uptake in rat striatum: A possible correlation between dopamine uptake and acetylcholine release inhibition

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Abstract

Optical isomers of deprenyl inhibit the resting and ouabain induced release of acetylcholine (ACh) in isolated striatal slices of the rat and this effect correlates with the capability of deprenyl to inhibit the uptake of 3H-dopamine in striatal homogenate in a concentration of 10 -4 -10 -4 M. The release of ACh is significantly increased in striatal slices taken from rats pretreated with a single dose of 250 μg of 6-hydroxydopamine. 5 mg/kg of deprenyl given 30 min prior to 6-hydroxydopamine treatment prevented completely the chemical destruction of the dopaminergic neurons. In contrast to deprenyl, clorgyline potentiated the effect of 6-hydroxydopamine.

Original languageEnglish
Pages (from-to)297-307
Number of pages11
JournalPolish journal of pharmacology and pharmacy
Volume31
Issue number4
Publication statusPublished - Dec 1 1979

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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