Inhibition and termination of physiological responses by GTPase activating proteins

E. Ligeti, Stefan Welti, Klaus Scheffzek

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Physiological processes are strictly organized in space and time. However, in cell physiology research, more attention is given to the question of space rather than to time. To function as a signal, environmental changes must be restricted in time; they need not only be initiated but also terminated. In this review, we concentrate on the role of one specific protein family involved in biological signal termination. GTPase activating proteins (GAPs) accelerate the endogenously low GTP hydrolysis rate of monomeric guanine nucleotide-binding proteins (GNBPs), limiting thereby their prevalence in the active, GTP-bound form. We discuss cases where defective or excessive GAP activity of specific proteins causes significant alteration in the function of the nervous, endocrine, and hemopoietic systems, or contributes to development of infections and tumors. Biochemical and genetic data as well as observations from human pathology support the notion that GAPs represent vital elements in the spatiotemporal fine tuning of physiological processes.

Original languageEnglish
Pages (from-to)237-272
Number of pages36
JournalPhysiological Reviews
Volume92
Issue number1
DOIs
Publication statusPublished - Jan 2012

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GTPase-Activating Proteins
Physiological Phenomena
Guanosine Triphosphate
Cell Physiological Phenomena
Endocrine System
Guanine Nucleotides
Molecular Biology
Carrier Proteins
Proteins
Hydrolysis
Pathology
Infection
Research
Neoplasms

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Physiology (medical)

Cite this

Inhibition and termination of physiological responses by GTPase activating proteins. / Ligeti, E.; Welti, Stefan; Scheffzek, Klaus.

In: Physiological Reviews, Vol. 92, No. 1, 01.2012, p. 237-272.

Research output: Contribution to journalArticle

Ligeti, E. ; Welti, Stefan ; Scheffzek, Klaus. / Inhibition and termination of physiological responses by GTPase activating proteins. In: Physiological Reviews. 2012 ; Vol. 92, No. 1. pp. 237-272.
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