Inhibiting effect of D1, but not D2 antagonist administered to the striatum on retention of passive avoidance in the chick

P. Kabai, Michael G. Stewart, József Tarcali, A. Csillág

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The avian lobus parolfactorius, equivalent to the medial striatum (caudate-putamen) of mammals, has been shown to be of crucial importance in passive avoidance training in day-old domestic chicks, where the aversive stimulus is the bitter tasting substance methylanthranilate. Here we report that the specific D1 antagonist SCH23390, injected into the lobus parolfactorius of day-old chicks (Gallus domesticus) prior to training, impaired performance on testing 30min post-training at low doses (0.5 and 25nmol). Sulpiride, a D2 antagonist, had no significant effect on performance in comparable doses. The early D1 activation may signify an essential mechanism leading to storage itself or to the canalisation of the relevant association to a permanent store.

Original languageEnglish
Pages (from-to)155-158
Number of pages4
JournalNeurobiology of Learning and Memory
Volume81
Issue number2
DOIs
Publication statusPublished - Mar 2004

Fingerprint

Sulpiride
Putamen
Mammals
Chickens
SCH 23390

Keywords

  • Avian brain
  • Avoidance training
  • Bird
  • Domestic chick
  • Dopamine
  • Learning
  • Memory
  • Striatum
  • Taste aversion

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Experimental and Cognitive Psychology

Cite this

Inhibiting effect of D1, but not D2 antagonist administered to the striatum on retention of passive avoidance in the chick. / Kabai, P.; Stewart, Michael G.; Tarcali, József; Csillág, A.

In: Neurobiology of Learning and Memory, Vol. 81, No. 2, 03.2004, p. 155-158.

Research output: Contribution to journalArticle

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