Inheritance and mapping of Compact (Cmpt), a new mutation causing hypermuscularity in mice

László Varga, Gyula Szabó, Ariel Darvasi, Géza Müller, Miklós Sass, Morris Soller

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

During selection for protein content in mice at the Technical University of Berlin, individuals showing high protein content and a compact exterior were noted. Animals showing this 'Compact' phenotype were separated to form a new line. The present investigations were carried out on a Hungarian subpopulation of this line, selected for maximum expression of the Compact phenotype, and apparently at fixation for the relevant genes. Fertility and viability of the Compact subpopulation was normal. As compared to normal mice, carcass percentage values for male and female Compact mice were 9.4 and 6.8% greater; respectively; and the muscle:bone weight ratio in males was 1.61-fold greater. The Compact phenotype showed variable expressivity and was of intermediate dominance in males, but almost fully recessive in females. The hypothesis that a single gene is solely responsible for the Compact phenotype was rejected by maximum likelihood analysis. Linkage mapping using selective DNA pooling located a single locus (denoted Cmpt) strongly associated with the Compact phenotype on mouse chromosome 1. Fine mapping, using individual selective genotyping and haplotype analysis, located Cmpt to the region between D1Mit375 and D1Mit21, approximately one third of the way to D1Mit21.

Original languageEnglish
Pages (from-to)755-764
Number of pages10
JournalGenetics
Volume147
Issue number2
Publication statusPublished - Oct 1997

Fingerprint

Phenotype
Mutation
Chromosome Mapping
Chromosomes, Human, Pair 1
Berlin
Haplotypes
Genes
Fertility
Proteins
Weights and Measures
Bone and Bones
Muscles
DNA

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Varga, L., Szabó, G., Darvasi, A., Müller, G., Sass, M., & Soller, M. (1997). Inheritance and mapping of Compact (Cmpt), a new mutation causing hypermuscularity in mice. Genetics, 147(2), 755-764.

Inheritance and mapping of Compact (Cmpt), a new mutation causing hypermuscularity in mice. / Varga, László; Szabó, Gyula; Darvasi, Ariel; Müller, Géza; Sass, Miklós; Soller, Morris.

In: Genetics, Vol. 147, No. 2, 10.1997, p. 755-764.

Research output: Contribution to journalArticle

Varga, L, Szabó, G, Darvasi, A, Müller, G, Sass, M & Soller, M 1997, 'Inheritance and mapping of Compact (Cmpt), a new mutation causing hypermuscularity in mice', Genetics, vol. 147, no. 2, pp. 755-764.
Varga L, Szabó G, Darvasi A, Müller G, Sass M, Soller M. Inheritance and mapping of Compact (Cmpt), a new mutation causing hypermuscularity in mice. Genetics. 1997 Oct;147(2):755-764.
Varga, László ; Szabó, Gyula ; Darvasi, Ariel ; Müller, Géza ; Sass, Miklós ; Soller, Morris. / Inheritance and mapping of Compact (Cmpt), a new mutation causing hypermuscularity in mice. In: Genetics. 1997 ; Vol. 147, No. 2. pp. 755-764.
@article{cd029e7e47ec4e9fad058754e5298026,
title = "Inheritance and mapping of Compact (Cmpt), a new mutation causing hypermuscularity in mice",
abstract = "During selection for protein content in mice at the Technical University of Berlin, individuals showing high protein content and a compact exterior were noted. Animals showing this 'Compact' phenotype were separated to form a new line. The present investigations were carried out on a Hungarian subpopulation of this line, selected for maximum expression of the Compact phenotype, and apparently at fixation for the relevant genes. Fertility and viability of the Compact subpopulation was normal. As compared to normal mice, carcass percentage values for male and female Compact mice were 9.4 and 6.8{\%} greater; respectively; and the muscle:bone weight ratio in males was 1.61-fold greater. The Compact phenotype showed variable expressivity and was of intermediate dominance in males, but almost fully recessive in females. The hypothesis that a single gene is solely responsible for the Compact phenotype was rejected by maximum likelihood analysis. Linkage mapping using selective DNA pooling located a single locus (denoted Cmpt) strongly associated with the Compact phenotype on mouse chromosome 1. Fine mapping, using individual selective genotyping and haplotype analysis, located Cmpt to the region between D1Mit375 and D1Mit21, approximately one third of the way to D1Mit21.",
author = "L{\'a}szl{\'o} Varga and Gyula Szab{\'o} and Ariel Darvasi and G{\'e}za M{\"u}ller and Mikl{\'o}s Sass and Morris Soller",
year = "1997",
month = "10",
language = "English",
volume = "147",
pages = "755--764",
journal = "Genetics",
issn = "0016-6731",
publisher = "Genetics Society of America",
number = "2",

}

TY - JOUR

T1 - Inheritance and mapping of Compact (Cmpt), a new mutation causing hypermuscularity in mice

AU - Varga, László

AU - Szabó, Gyula

AU - Darvasi, Ariel

AU - Müller, Géza

AU - Sass, Miklós

AU - Soller, Morris

PY - 1997/10

Y1 - 1997/10

N2 - During selection for protein content in mice at the Technical University of Berlin, individuals showing high protein content and a compact exterior were noted. Animals showing this 'Compact' phenotype were separated to form a new line. The present investigations were carried out on a Hungarian subpopulation of this line, selected for maximum expression of the Compact phenotype, and apparently at fixation for the relevant genes. Fertility and viability of the Compact subpopulation was normal. As compared to normal mice, carcass percentage values for male and female Compact mice were 9.4 and 6.8% greater; respectively; and the muscle:bone weight ratio in males was 1.61-fold greater. The Compact phenotype showed variable expressivity and was of intermediate dominance in males, but almost fully recessive in females. The hypothesis that a single gene is solely responsible for the Compact phenotype was rejected by maximum likelihood analysis. Linkage mapping using selective DNA pooling located a single locus (denoted Cmpt) strongly associated with the Compact phenotype on mouse chromosome 1. Fine mapping, using individual selective genotyping and haplotype analysis, located Cmpt to the region between D1Mit375 and D1Mit21, approximately one third of the way to D1Mit21.

AB - During selection for protein content in mice at the Technical University of Berlin, individuals showing high protein content and a compact exterior were noted. Animals showing this 'Compact' phenotype were separated to form a new line. The present investigations were carried out on a Hungarian subpopulation of this line, selected for maximum expression of the Compact phenotype, and apparently at fixation for the relevant genes. Fertility and viability of the Compact subpopulation was normal. As compared to normal mice, carcass percentage values for male and female Compact mice were 9.4 and 6.8% greater; respectively; and the muscle:bone weight ratio in males was 1.61-fold greater. The Compact phenotype showed variable expressivity and was of intermediate dominance in males, but almost fully recessive in females. The hypothesis that a single gene is solely responsible for the Compact phenotype was rejected by maximum likelihood analysis. Linkage mapping using selective DNA pooling located a single locus (denoted Cmpt) strongly associated with the Compact phenotype on mouse chromosome 1. Fine mapping, using individual selective genotyping and haplotype analysis, located Cmpt to the region between D1Mit375 and D1Mit21, approximately one third of the way to D1Mit21.

UR - http://www.scopus.com/inward/record.url?scp=0030763608&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030763608&partnerID=8YFLogxK

M3 - Article

VL - 147

SP - 755

EP - 764

JO - Genetics

JF - Genetics

SN - 0016-6731

IS - 2

ER -