Informative morphogenetic variants as markers in schizophrenia

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Objective: The authors evaluated the importance of informative morphogenetic variants as somatic markers in schizophrenia. Methods: They report about their investigation among 50 schizophrenic and 50 alcohol-dependent patients. Taking into consideration the shortcomings of the Waldropscale, the authors used an IMV-list, completed by Méhes, which contains 56 items, and makes a clear distinction between minor malformation (those developing during organogenesis) and phenogenetic variants (those developing after organogenesis). In accordance with the literature, an interrater agreement among the three independent raters above 75% was considered reliable. Results: Forty-three of the 56 informative morphogenetic variants met the authors' reliability criterion, which have been statistically evaluated. Patients with schizophrenia had significantly higher rates of eight informative morphogenetic variants, five minor malformations, and three phenogenetic variants. Among the five minor malformations, two were referring to the oral area (multiple buccal frenula, furrowed tongue), one to the head (double whorl), one to the hand (simian crease), and one to the skin (hemangioma). Conclusions: Considering that during intrauterine life ectodermal development is in close parallelity with neuronal development, the investigation of informative morphogenetic variants, using the completed list by Méhes, is helpful to a better timing of intrauterine damage. The results suggest that using a finer distinction in the evaluation of informative morphogenetic variants in schizophrenia may be useful for a possible construction of a neurodevelopmental subgroup of schizophrenia.

Original languageEnglish
Number of pages1
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Issue number6
Publication statusPublished - Nov 6 1998


ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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