Influence of the physicochemical parameters of propargylamine derivatives on their retention on p-cyclodextrin polymer-coated support

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Abstract

The retention of 17 propargylamine derivatives was determined on a B-cyclodextrin polymer (B-CDP)-coated silica column using dioxane-0.05 M K2HP04 (6:4, v/v) as eluent. The inclusion complex formation between the propargylamine derivatives and a water-soluble 6-CD polymer was studied by charge-transfer chromatography carried out on reversed-phase TLC layers. The capacity factors were correlated with the various physicochemical parameters of the solutes. Principal component analysis proved that the hydrophobicity and steric parameters have the highest influence on the retention of propargylamine derivatives in HPLC. The result suggest that the selectivity of the 6-CDP-coated silica support may be different from that of the traditional alkyl bonded reversed-phase supports.

Original languageEnglish
Pages (from-to)2783-2799
Number of pages17
JournalJournal of Liquid Chromatography
Volume18
Issue number14
DOIs
Publication statusPublished - Aug 1 1995

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ASJC Scopus subject areas

  • Molecular Medicine

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