The aim of the present study was to formulate suspension type inhalation aerosols by various types of auxiliary materials, and to select the formulation with the highest proportion of the effective particle size. The examined suspension type aerosol contained sodium cromoglycate as an active compound. For the stabilization of the suspension, the applied surface active ingredients were oleic acid and oleyl oleate, and dimethyl siloxane polymer was selected as hydrophobizing agent. Factorial design was used for the optimization of the experimental results. On the basis of our results, the correct types and amounts of auxiliary materials can be selected to obtain the therapeutically effective formulation.
|Translated title of the contribution||Influence of the auxiliary materials on the proportion of the effective particle size of metered-dose suspension-type aerosols|
|Number of pages||4|
|Journal||Acta pharmaceutica Hungarica|
|Publication status||Published - Jul 1 1998|
ASJC Scopus subject areas
- Pharmaceutical Science